Buscar
Mostrando ítems 1-10 de 206
Genetic diversity of VAR2CSA ID1-DBL2Xb in worldwide Plasmodium falciparum populations: impact on vaccine design for placental malaria
(Elsevier, 2014)
In placental malaria (PM), sequestration of infected erythrocytes in the placenta is mediated by an interaction between VAR2CSA, a Plasmodium falciparum protein expressed on erythrocytes, and chondroitin sulfate A (CSA) ...
International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact
(Elsevier, 2019)
Background: Pneumococcal conjugate vaccines have reduced the incidence of invasive pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a concern. We used whole genome sequencing to study ...
Genome-level determination of Plasmodium falciparum blood-stage targets of malarial clinical immunity in the Peruvian Amazon
(Oxford University Press, 2015)
BACKGROUND: Persons with blood-stage Plasmodium falciparum parasitemia in the absence of symptoms are considered to be clinically immune. We hypothesized that asymptomatic subjects with P. falciparum parasitemia would ...
Burden of Norovirus and Rotavirus in Children After Rotavirus Vaccine Introduction, Cochabamba, Bolivia
(American Society of Tropical Medicine and Hygiene, 2016)
The effectiveness of rotavirus vaccine in the field may set the stage for a changing landscape of diarrheal illness affecting children worldwide. Norovirus and rotavirus are the two major viral enteropathogens of childhood. ...
Plant-based vaccine for livestock : key points to unleash platform translation in developing countries
(2016-12)
Ten years ago the first plant-based vaccine was licensed (DowAgrosciences). It was only 20 years after the first report of a recombinant protein obtained through plant transformation technology. Back then, this vaccine was ...
Genetically attenuated Trypanosoma cruzi parasites as a potential vaccination tool
(Taylor & Francis, 2012-06-18)
Chagas disease is the clinical manifestation of the infection produced by the parasite Trypanosoma cruzi. Currently there is no vaccine to prevent this disease and the protection attained with vaccines containing non-replicating ...